Infections with a predominantly sexual mode of transmission

tabes dorsalis: A tertiary neurosyphilis that results_in slow degeneration of the nerve cells and nerve fibers that carry sensory information to the brain. The infection has_symptom intense, stabbing pain in the back and legs that recurs irregularly, has_symptom gait ataxia, has_symptom hyperesthesia, has_symptom paresthesia, has_symptom loss of bladder sensation leading to urine retention, has_symptom erectile dysfunction.

Endpoint definition

FinnGen phenotype data
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Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 A50-A64
Hospital discharge: ICD-9 09[0-9]|0541|131|0781C
Hospital discharge: ICD-8 09[0-9]|131
Cause of death: ICD-10 A50-A64
Cause of death: ICD-9 09[0-9]|0541|131|0781C
Cause of death: ICD-8 09[0-9]|131

Check pre-conditions None

Check conditions None

Apply sex-specific rule None

diagram downward connector AB1_SEXUAL_TRANSMISSION

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Similar endpoints

List of similar endpoints to Infections with a predominantly sexual mode of transmission based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

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Summary Statistics

Key figures

All Female Male
Number of individuals 7059 5163 1896
Unadjusted prevalence (%) 2.71 3.51 1.68
Mean age at first event (years) 32.55 31.28 36.02

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.52 [0.80, 2.86] 2.0e-1 188
15 years 0.01 1.78 [1.02, 3.12] 4.3e-2 123
5 years 0.00 3.35 [1.99, 5.64] 5.2e-6 47
1 year 0.00 5.56 [2.84, 10.89] 5.5e-7 14

Correlations

Index endpoint: AB1_SEXUAL_TRANSMISSION – Infections with a predominantly sexual mode of transmission
GWS hits: 0

Survival analyses between endpoints

Plot

before Infections with a predominantly sexual mode of transmission
after Infections with a predominantly sexual mode of transmission

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Drugs most likely to be purchased after Infections with a predominantly sexual mode of transmission