Viral infections of the central nervous system

viral meningitis: Viral infections of the leptomeninges and subarachnoid space. TOGAVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; RUBELLA; BUNYAVIRIDAE INFECTIONS; ORBIVIRUS infections; PICORNAVIRIDAE INFECTIONS; ORTHOMYXOVIRIDAE INFECTIONS; RHABDOVIRIDAE INFECTIONS; ARENAVIRIDAE INFECTIONS; HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; JC VIRUS infections; and RETROVIRIDAE INFECTIONS may cause this form of meningitis. Clinical manifestations include fever, headache, neck pain, vomiting, PHOTOPHOBIA, and signs of meningeal irritation. (From Joynt, Clinical Neurology, 1996, Ch26, pp1-3)

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 A80-A89
Hospital discharge: ICD-9 04[5-9]|071|06[2-4]
Hospital discharge: ICD-8 04[0-3]|06[2-5]|071
Cause of death: ICD-10 A80-A89
Cause of death: ICD-9 04[5-9]|071|06[2-4]
Cause of death: ICD-8 04[0-3]|06[2-5]|071

Check pre-conditions None

Check conditions None

Apply sex-specific rule None

diagram downward connector AB1_VIRAL_CNS

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Similar endpoints

List of similar endpoints to Viral infections of the central nervous system based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

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Summary Statistics

Key figures

All Female Male
Number of individuals 1394 840 554
Unadjusted prevalence (%) 0.54 0.57 0.49
Mean age at first event (years) 37.44 36.38 39.04

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 3.64 [2.16, 6.14] 1.2e-6 140
15 years 0.03 4.54 [2.93, 7.06] 1.5e-11 108
5 years 0.01 10.55 [7.13, 15.60] 4.2e-32 59
1 year - - - -

Correlations

Index endpoint: AB1_VIRAL_CNS – Viral infections of the central nervous system
GWS hits: 0

Survival analyses between endpoints

Plot

before Viral infections of the central nervous system
after Viral infections of the central nervous system

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Drugs most likely to be purchased after Viral infections of the central nervous system