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Colon adenocarcinoma

DOIDEFOMESH PheWeb

colon adenocarcinoma: An adenocarcinoma arising from the colon. It is more frequently seen in populations with a Western type diet and in patients with a history of chronic inflammatory bowel disease. Signs and symptoms include intestinal bleeding, anemia, and change in bowel habits. According to the degree of cellular differentiation, colonic adenocarcinomas are divided into well, moderately, and poorly differentiated. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma.

Endpoint definition

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FinnGen phenotype data
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Filter registries Death, Cancer

Cause of death: ICD-10 C18
Cause of death: ICD-9 153
Cause of death: ICD-8 153
Cancer registry: Topography ICD-O-3 C18
Cancer registry: Morphology ICD-O-3 8140
Cancer registry: Behaviour codes 3

Check pre-conditions None

Include endpoints None

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Check conditions

HLP_C3_COLON_ADENO

Apply sex-specific rule None

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Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF4

Summary Statistics

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Key figures

All Female Male
Number of individuals 2008 909 1099
Unadjusted prevalence (%) 0.77 0.62 0.97
Mean age at first event (years) 67.29 66.37 68.06

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 4.51 [3.37, 6.04] 3.7e-24 545
15 years - - - -
5 years - - - -
1 year - - - -

Correlations

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Index endpoint: C3_COLON_ADENO – Colon adenocarcinoma
GWS hits: 3

Survival analyses between endpoints

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Plot

before Colon adenocarcinoma
after Colon adenocarcinoma

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Colon adenocarcinoma

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