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Hypoparathyroidism

DOIDEFOMESHSNOMED PheWeb

hypoparathyroidism: Hypoparathyroidism is is an endocrine disorder in which the parathyroid glands in the neck do not produce enough parathyroid hormone (PTH). Common signs and symptoms includeabdominal pain, brittle nails, cataracts, dry hair and skin,muscle cramps,tetany, pain in the face, legs, and feet, seizures, tingling sensation,and weakened tooth enamel (in children). It may be caused byinjury to the parathyroid glands (e.g., during surgery). Other causes, include low blood magnesium levels, a side effect of radioactive iodine treatment for hyperthyroidism , metabolic alkalosis , DiGeorge syndrome , and type I polyglandular autoimmune syndrome . The goal of treatment is to restore the calcium and mineral balance in the body.

Endpoint definition

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FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death, KELA purch., KELA reimb.

Hospital Discharge: ICD-10 E20
Hospital discharge: ICD-9 2521
Hospital discharge: ICD-8 2521
Cause of death: ICD-10 E20
Cause of death: ICD-9 2521
Cause of death: ICD-8 2521
KELA reimbursements: KELA codes 106
Medicine purchases: ATC H05AA
Medicine purchases: ATC: other data required >3 instances required

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector E4_HYPOPARA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E20-E35
Name in latin Hypoparathyreoidismus

Summary Statistics

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Key figures

All Female Male
Number of individuals 617 487 130
Unadjusted prevalence (%) 0.24 0.33 0.11
Mean age at first event (years) 55.81 55.72 56.13

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 4.04 [2.43, 6.73] 7.9e-8 53
15 years 0.03 3.68 [2.06, 6.56] 1.0e-5 40
5 years 0.01 5.98 [2.64, 13.56] 1.8e-5 28
1 year - - - -

Correlations

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Index endpoint: E4_HYPOPARA – Hypoparathyroidism
GWS hits: 1

Survival analyses between endpoints

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Plot

before Hypoparathyroidism
after Hypoparathyroidism

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Hypoparathyroidism

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