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Hypopituitarism

DOIDEFOMESHSNOMED PheWeb

hypopituitarism: A condition of diminution or cessation of secretion of one or more hormones from the anterior pituitary gland. This may result from surgical or radiation ablation, non-secretory pituitary neoplasms, metastatic tumors, infarction, pituitary apoplexy, infiltrative or granulomatous processes, and other conditions.

Endpoint definition

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FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death, KELA purch., KELA reimb.

Hospital Discharge: ICD-10 E23.00, E23.01, E23.02, E23.03, E23.04, E23.05, E23.06, E23.08, E23.09
Hospital discharge: ICD-9 2532
Hospital discharge: ICD-8 2531
Cause of death: ICD-10 E23.00, E23.01, E23.02, E23.03, E23.04, E23.05, E23.06, E23.08, E23.09
Cause of death: ICD-9 2532
Cause of death: ICD-8 2531
KELA reimbursements: KELA codes 101

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector E4_HYPOPIT

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 1085 407 678
Unadjusted prevalence (%) 0.42 0.28 0.60
Mean age at first event (years) 43.18 41.70 44.07

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.52 [0.57, 4.11] 4.0e-1 61
15 years 0.01 1.87 [0.79, 4.41] 1.5e-1 49
5 years 0.00 4.49 [2.20, 9.16] 3.7e-5 27
1 year - - - -

Correlations

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Index endpoint: E4_HYPOPIT – Hypopituitarism
GWS hits: 3

Survival analyses between endpoints

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Plot

before Hypopituitarism
after Hypopituitarism

loading spinner Loading survival analyses plot