Depression

unipolar depression: A mood disorder having a clinical course involving one or more episodes of serious psychological depression that last two or more weeks each, do not have intervening episodes of mania or hypomania, and are characterized by a loss of interest or pleasure in almost all activities and by some or all of disturbances of appetite, sleep, or psychomotor functioning, a decrease in energy, difficulties in thinking or making decisions, loss of self-esteem or feelings of guilt, and suicidal thoughts or attempts.

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 F32, F33
Hospital discharge: ICD-9 2961|2968|3004
Hospital discharge: ICD-8 79020|2980
Cause of death: ICD-10 F32, F33
Cause of death: ICD-9 2961|2968|3004
Cause of death: ICD-8 79020|2980

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector F5_DEPRESSIO

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF6

Summary Statistics

Key figures

All Female Male
Number of individuals 28098 18572 9526
Unadjusted prevalence (%) 10.81 12.64 8.42
Mean age at first event (years) 41.22 40.15 43.30

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 3.23 [2.79, 3.73] 1.4e-55 1807
15 years 0.02 3.87 [3.43, 4.36] <1e-100 1469
5 years 0.01 6.23 [5.51, 7.05] <1e-100 655
1 year 0.00 10.98 [9.13, 13.20] <1e-100 226

Correlations

Index endpoint: F5_DEPRESSIO – Depression
GWS hits: 4

Survival analyses between endpoints

Plot

before Depression
after Depression

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