Alzheimer disease

Alzheimer's disease: A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.

Endpoint definition

FinnGen phenotype data
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Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 G30
Hospital discharge: ICD-9 3310
Cause of death: ICD-10 G30
Cause of death: ICD-9 3310

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector G6_ALZHEIMER

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G30-G32
Name in latin Morbus Alzheimer

Summary Statistics

Key figures

All Female Male
Number of individuals 4497 2235 2262
Unadjusted prevalence (%) 1.73 1.52 2.00
Mean age at first event (years) 78.94 79.37 78.50

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.18 12.28 [10.31, 14.62] <1e-100 2578
15 years 0.09 12.23 [10.27, 14.57] <1e-100 2568
5 years 0.02 13.96 [12.27, 15.88] <1e-100 1927
1 year 0.01 22.94 [19.69, 26.73] <1e-100 815

Correlations

Index endpoint: G6_ALZHEIMER – Alzheimer disease
GWS hits: 2

Survival analyses between endpoints

Plot

before Alzheimer disease
after Alzheimer disease

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Drugs most likely to be purchased after Alzheimer disease