Normal-pressure hydrocephalus

normal pressure hydrocephalus: A form of compensated hydrocephalus characterized clinically by a slowly progressive gait disorder (see gait disorders, neurologic), progressive intellectual decline, and urinary incontinence. Spinal fluid pressure tends to be in the high normal range. This condition may result from processes which interfere with the absorption of csf including subarachnoid hemorrhage, chronic meningitis, and other conditions. (From Adams et al., Principles of Neurology, 6th ed, pp631-3)

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 G91.2
Cause of death: ICD-10 G91.2

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector G6_HCNP

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G91
Name in latin Hydrocephalia normotensiva

Summary Statistics

Key figures

All Female Male
Number of individuals 384 178 206
Unadjusted prevalence (%) 0.15 0.12 0.18
Mean age at first event (years) 69.22 68.96 69.45

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.10 6.91 [3.82, 12.51] 1.6e-10 83
15 years 0.05 6.92 [3.82, 12.54] 1.7e-10 83
5 years - - - -
1 year - - - -

Correlations

Index endpoint: G6_HCNP – Normal-pressure hydrocephalus
GWS hits: 1

Survival analyses between endpoints

Plot

before Normal-pressure hydrocephalus
after Normal-pressure hydrocephalus

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Normal-pressure hydrocephalus