Postpolio syndrome

DOID EFO MESH SNOMED PheWeb

postpoliomyelitis syndrome: Postpoliomyelitis syndrome (PPS) is a neurologic disorder characterized by the development of new neuromuscular symptoms such as progressive muscular weakness or abnormal muscle fatigability occurring in survivors of the acute paralytic form of poliomyelitis (see this term), 15-40 years after recovery from the disease, and that is unexplained by other medical causes. Other manifestations that can occur gradually include generalized fatigue, muscle atrophy, muscle and joint pain, intolerance to cold, and difficulties sleeping, swallowing or breathing.

Endpoint definition

↥

FinnGen phenotype data

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 G14

Hospital discharge: ICD-9 138

Hospital discharge: ICD-8 4499

Cause of death: ICD-10 G14

Cause of death: ICD-9 138

Cause of death: ICD-8 4499

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

G6_POSTPOLIO

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Similar endpoints

↥

List of similar endpoints to Postpolio syndrome based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

↥

Key figures

	All	Female	Male
Number of individuals	46	30	16
Unadjusted prevalence (%)	0.02	0.02	0.01
Mean age at first event (years)	48.96	48.51	49.81

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Correlations

↥

Index endpoint: G6_POSTPOLIO – Postpolio syndrome
GWS hits:

Survival analyses between endpoints

↥

Plot

before Postpolio syndrome
after Postpolio syndrome

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Postpolio syndrome

↥