Other extrapyramidal and movement disorders+ in other diseases

DOID EFO MESH SNOMED PheWeb

Stiff-Person syndrome: Stiff-man syndrome (SMS) is a rare neurological disorder comprising fluctuating trunk and limb stiffness, painful muscle spasms, task-specific phobia, an exaggerated startle response, and ankylosing deformities such as fixed lumbar hyperlordosis.

Endpoint definition

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FinnGen phenotype data

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 G25, G26*

Hospital discharge: ICD-9 333

Hospital discharge: excluded ICD-9 3330|3336

Cause of death: ICD-10 G25, G26*

Cause of death: ICD-9 333

Cause of death: excluded ICD-9 3330|3336

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

G6_XTRAPYROTH

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Other extrapyramidal and movement disorders+ in other diseases based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	2638	1406	1232
Unadjusted prevalence (%)	1.01	0.96	1.09
Mean age at first event (years)	59.16	57.12	61.49

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	1.75 [1.11, 2.76]	1.6e-2	307
15 years	0.02	2.19 [1.48, 3.22]	7.9e-5	283
5 years	0.00	3.65 [2.69, 4.95]	9.6e-17	133
1 year	0.00	5.02 [3.31, 7.63]	3.7e-14	34

Correlations

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Index endpoint: G6_XTRAPYROTH – Other extrapyramidal and movement disorders+ in other diseases
GWS hits: 0

Survival analyses between endpoints

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Plot

before Other extrapyramidal and movement disorders+ in other diseases
after Other extrapyramidal and movement disorders+ in other diseases

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Table

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Drugs most likely to be purchased after Other extrapyramidal and movement disorders+ in other diseases

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