Primary open-angle glaucoma, strict

DOID EFO MESH SNOMED PheWeb

open-angle glaucoma: Chronic outflow obstruction of the eye's drainage canals that can lead to increased internal eye pressure and optic nerve damage.

Endpoint definition

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FinnGen phenotype data

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 H40.1

Hospital discharge: ICD-9 3651[A|C|E|X]

Hospital discharge: ICD-8 37510

Hospital discharge: excluded ICD-10 H40.10, H40.12

Cause of death: ICD-10 H40.1

Cause of death: ICD-9 3651[A|C|E|X]

Cause of death: ICD-8 37510

Cause of death: excluded ICD-10 H40.10, H40.12

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

H7_GLAUCOMA_POAG

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF4

Parent code in ICD-10 H40

Name in latin Glaucoma simplex primarium

Similar endpoints

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List of similar endpoints to Primary open-angle glaucoma, strict based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Juvenile Open Angle Glaucoma

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	4163	2318	1845
Unadjusted prevalence (%)	1.60	1.58	1.63
Mean age at first event (years)	66.36	66.15	66.62

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	1.88 [1.47, 2.40]	4.4e-7	669
15 years	0.01	1.95 [1.56, 2.44]	4.2e-9	570
5 years	0.00	2.06 [1.69, 2.53]	2.7e-12	208
1 year	0.00	2.34 [1.67, 3.28]	8.9e-7	45

Correlations

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Index endpoint: H7_GLAUCOMA_POAG – Primary open-angle glaucoma, strict
GWS hits: 15

Survival analyses between endpoints

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Plot

before Primary open-angle glaucoma, strict
after Primary open-angle glaucoma, strict

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Table

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Drugs most likely to be purchased after Primary open-angle glaucoma, strict

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