Disorders of lens

DOID EFO MESH SNOMED PheWeb

cataract: Partial or complete opacity of the crystalline lens of one or both eyes that decreases visual acuity and eventually results in blindness. Some cataracts appear in infancy or in childhood, but most develop in older individuals. (Sternberg Diagnostic Surgical Pathology, 3rd ed.)

Endpoint definition

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FinnGen phenotype data

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 H25-H28, H28.2*G71.11

Cause of death: ICD-10 H25-H28, H28.2*G71.11

Check pre-conditions None

Include endpoints

H7_CATARACTSENILE

H7_CATARACTOTHER

H7_APHAKIA

H7_LENSDISLOCATIO

H7_DISORDERLENSNAS

Check conditions None

Apply sex-specific rule None

H7_LENS

Extra metadata

Level in the ICD hierarchy 2

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Disorders of lens based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	35583	19748	15835
Unadjusted prevalence (%)	13.68	13.44	14.00
Mean age at first event (years)	69.38	69.37	69.41

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.04	2.66 [2.40, 2.95]	1.8e-76	7279
15 years	0.02	2.88 [2.63, 3.16]	<1e-100	6704
5 years	0.00	3.55 [3.25, 3.87]	<1e-100	2988
1 year	0.00	3.16 [2.74, 3.65]	6.3e-55	571

Correlations

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Index endpoint: H7_LENS – Disorders of lens
GWS hits: 21

Survival analyses between endpoints

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Plot

before Disorders of lens
after Disorders of lens

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Table

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Drugs most likely to be purchased after Disorders of lens

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