Disorders of ocular muscles, binocular movement, accommodation and refraction

trochlear nerve disease: Diseases of the fourth cranial (trochlear) nerve or its nucleus in the midbrain. The nerve crosses as it exits the midbrain dorsally and may be injured along its course through the intracranial space, cavernous sinus, superior orbital fissure, or orbit. Clinical manifestations include weakness of the superior oblique muscle which causes vertical DIPLOPIA that is maximal when the affected eye is adducted and directed inferiorly. Head tilt may be seen as a compensatory mechanism for diplopia and rotation of the visual axis. Common etiologies include CRANIOCEREBRAL TRAUMA and INFRATENTORIAL NEOPLASMS.

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 H49-H52
Cause of death: ICD-10 H49-H52

Check pre-conditions None

Check conditions None

Apply sex-specific rule None

diagram downward connector H7_OCUMUSCLE

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 9461 5935 3526
Unadjusted prevalence (%) 3.64 4.04 3.12
Mean age at first event (years) 36.56 34.51 40.01

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.81 [1.38, 2.38] 1.9e-5 514
15 years 0.01 2.12 [1.68, 2.67] 2.8e-10 417
5 years 0.00 3.18 [2.52, 4.02] 3.3e-22 177
1 year 0.00 5.79 [4.20, 7.97] 5.9e-27 58

Correlations

Index endpoint: H7_OCUMUSCLE – Disorders of ocular muscles, binocular movement, accommodation and refraction
GWS hits: 1

Survival analyses between endpoints

Plot

before Disorders of ocular muscles, binocular movement, accommodation and refraction
after Disorders of ocular muscles, binocular movement, accommodation and refraction

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Drugs most likely to be purchased after Disorders of ocular muscles, binocular movement, accommodation and refraction