Optic neuritis

optic neuritis: Optic neuritis is inflammation of the optic nerve, the nerve that carries the visual signal from the eye to the brain.The conditionmay cause sudden, reduced vision in the affected eye(s). While the cause of optic neuritis is unknown, it has been associated with autoimmune diseases, infections, multiple sclerosis , drug toxicity and deficiency of vitamin B-12. Vision often returns to normal within 2-3 weeks without treatment. In some cases, corticosteroids are given to speed recovery. If known, the underlying cause should be treated.

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 H46
Hospital discharge: ICD-9 3773
Hospital discharge: ICD-8 3670[2-9]
Cause of death: ICD-10 H46
Cause of death: ICD-9 3773
Cause of death: ICD-8 3670[2-9]

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector H7_OPTNEURITIS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H46-H48
Name in latin Neuritis optica

Summary Statistics

Key figures

All Female Male
Number of individuals 749 559 190
Unadjusted prevalence (%) 0.29 0.38 0.17
Mean age at first event (years) 38.58 37.41 42.04

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.17 [0.26, 5.22] 8.4e-1 40
15 years 0.01 1.51 [0.37, 6.27] 5.7e-1 26
5 years - - - -
1 year - - - -

Correlations

Index endpoint: H7_OPTNEURITIS – Optic neuritis
GWS hits: 1

Survival analyses between endpoints

Plot

before Optic neuritis
after Optic neuritis

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