Cholesteatoma of middle ear

cholesteatoma of middle ear: A non-neoplastic lesion characterized by the proliferation of keratinizing squamous epithelium in the middle ear that results in the accumulation of keratin and cells. It is usually caused by repeated infections. If left untreated, it may increase in size and destroy the adjacent delicate bones of the middle ear.

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 H71
Hospital discharge: ICD-9 3853
Hospital discharge: ICD-8 38700
Cause of death: ICD-10 H71
Cause of death: ICD-9 3853
Cause of death: ICD-8 38700

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector H8_CHOLEASTOMA

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H65-H75
Name in latin Cholesteatoma auris mediae

Summary Statistics

Key figures

All Female Male
Number of individuals 954 440 514
Unadjusted prevalence (%) 0.37 0.30 0.45
Mean age at first event (years) 46.79 45.62 47.80

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.89 [1.28, 2.79] 1.4e-3 124
15 years 0.01 1.94 [1.37, 2.74] 1.8e-4 86
5 years 0.00 2.40 [1.51, 3.80] 2.0e-4 26
1 year - - - -

Correlations

Index endpoint: H8_CHOLEASTOMA – Cholesteatoma of middle ear
GWS hits: 0

Survival analyses between endpoints

Plot

before Cholesteatoma of middle ear
after Cholesteatoma of middle ear

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Cholesteatoma of middle ear