Ménière disease

endolymphatic hydrops: An accumulation of endolymph in the inner ear (labyrinth) leading to buildup of pressure and distortion of intralabyrinthine structures, such as cochlea and semicircular canals. It is characterized by sensorineural hearing loss; tinnitus; and sometimes vertigo.

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 H81.0
Hospital discharge: ICD-9 3860
Hospital discharge: ICD-8 38599
Cause of death: ICD-10 H81.0
Cause of death: ICD-9 3860
Cause of death: ICD-8 38599

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector H8_MENIERE

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H81
Name in latin Morbus Ménière

Summary Statistics

Key figures

All Female Male
Number of individuals 1791 1167 624
Unadjusted prevalence (%) 0.69 0.79 0.55
Mean age at first event (years) 55.12 54.30 56.64

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.20 [0.79, 1.82] 3.9e-1 133
15 years 0.01 1.40 [0.96, 2.03] 7.8e-2 97
5 years 0.00 1.87 [1.15, 3.06] 1.2e-2 34
1 year - - - -

Correlations

Index endpoint: H8_MENIERE – Ménière disease
GWS hits: 1

Survival analyses between endpoints

Plot

before Ménière disease
after Ménière disease

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Ménière disease