Cerebral amyloid angiopathy

DOID EFO MESH SNOMED PheWeb

cerebral amyloid angiopathy: Hereditary cerebral hemorrhage with amyloidosis (HCHWA) describes a group of rare familial central nervous system disorders characterized by amyloid deposition in the cerebral blood vessels leading to hemorrhagic and non-hemorrhagic strokes, focal neurological deficits, and progressive cognitive decline eventually leading to dementia.

Endpoint definition

↥

FinnGen phenotype data

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 I68.0*, I68.0*E85.9

Cause of death: ICD-10 I68.0*, I68.0*E85.9

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

I9_CEREBAMY

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Similar endpoints

↥

List of similar endpoints to Cerebral amyloid angiopathy based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

↥

Key figures

	All	Female	Male
Number of individuals	29	10	19
Unadjusted prevalence (%)	0.01	0.01	0.02
Mean age at first event (years)	68.09	66.66	68.84

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Correlations

↥

Index endpoint: I9_CEREBAMY – Cerebral amyloid angiopathy
GWS hits:

Survival analyses between endpoints

↥

Plot

before Cerebral amyloid angiopathy
after Cerebral amyloid angiopathy

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Cerebral amyloid angiopathy

↥