Valvular heart disease including rheumatic fever

heart valve disease: A disease involving the cardial valve.

Endpoint definition

FinnGen phenotype data

Filter registries None

Check pre-conditions None

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Include endpoints

Check conditions None

Apply sex-specific rule None

diagram downward connector I9_VHD

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 46989 22586 24403
Unadjusted prevalence (%) 18.07 15.37 21.58
Mean age at first event (years) 60.98 59.61 62.25

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 3.78 [3.36, 4.25] <1e-100 5684
15 years 0.03 4.21 [3.79, 4.67] <1e-100 5467
5 years 0.01 6.62 [6.06, 7.22] <1e-100 3260
1 year 0.00 12.00 [10.55, 13.65] <1e-100 1188

Correlations

Index endpoint: I9_VHD – Valvular heart disease including rheumatic fever
GWS hits: 12

Survival analyses between endpoints

Plot

before Valvular heart disease including rheumatic fever
after Valvular heart disease including rheumatic fever

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Drugs most likely to be purchased after Valvular heart disease including rheumatic fever