ILD related to systemic autoimmune disease

interstitial lung disease: A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of pulmonary alveoli that extends to the interstitium and beyond leading to diffuse pulmonary fibrosis. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.

Endpoint definition

FinnGen phenotype data

Filter registries None

Check pre-conditions None

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Include endpoints

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Check conditions

ILD_ELSEWHERE

Apply sex-specific rule None

diagram downward connector ILD_SYST_AUTO

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 498 249 249
Unadjusted prevalence (%) 0.19 0.17 0.22
Mean age at first event (years) 54.06 52.90 55.22

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.07 5.12 [3.41, 7.70] 3.8e-15 98
15 years 0.03 4.84 [3.18, 7.38] 2.0e-13 82
5 years 0.01 5.80 [3.57, 9.43] 1.4e-12 32
1 year - - - -

Correlations

Index endpoint: ILD_SYST_AUTO – ILD related to systemic autoimmune disease
GWS hits: 1

Survival analyses between endpoints

Plot

before ILD related to systemic autoimmune disease
after ILD related to systemic autoimmune disease

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Drugs most likely to be purchased after ILD related to systemic autoimmune disease