Cholangitis (primary sclerosing, PSC)

sclerosing cholangitis: A chronic, autoimmune inflammatory liver disorder characterized by narrowing and scarring of the lumen of the bile ducts. It is often seen in patients with ulcerative colitis. Signs and symptoms include jaundice, fatigue, and malabsorption. It may lead to cirrhosis and liver failure.

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 K83.0
Hospital discharge: ICD-9 5761
Hospital discharge: ICD-8 5750[4-5]
Cause of death: ICD-10 K83.0
Cause of death: ICD-9 5761
Cause of death: ICD-8 5750[4-5]

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector K11_CHOLANGI

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K83
Name in latin Cholangitis

Similar endpoints

List of similar endpoints to Cholangitis (primary sclerosing, PSC) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 952 468 484
Unadjusted prevalence (%) 0.37 0.32 0.43
Mean age at first event (years) 56.01 53.73 58.22

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Correlations

Index endpoint: K11_CHOLANGI – Cholangitis (primary sclerosing, PSC)
GWS hits: 0

Survival analyses between endpoints

Plot

before Cholangitis (primary sclerosing, PSC)
after Cholangitis (primary sclerosing, PSC)

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Drugs most likely to be purchased after Cholangitis (primary sclerosing, PSC)