Diaphragmatic hernia

DOID EFO MESH PheWeb

congenital diaphragmatic hernia: Congenital diaphragmatic hernia (CDH) is a posterolateral defect of the diaphragm that allows passage of abdominal viscera into the thorax, leading to respiratory insufficiency and persistent pulmonary hypertension with high mortality.

Endpoint definition

↥

FinnGen phenotype data

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 K44

Hospital discharge: ICD-9 5513|5523|5533

Hospital discharge: ICD-8 5513

Cause of death: ICD-10 K44

Cause of death: ICD-9 5513|5523|5533

Cause of death: ICD-8 5513

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

K11_DIAHER

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 K40-K46

Name in latin Hernia diaphragmatica

Similar endpoints

↥

List of similar endpoints to Diaphragmatic hernia based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

↥

Key figures

	All	Female	Male
Number of individuals	7023	4193	2830
Unadjusted prevalence (%)	2.70	2.85	2.50
Mean age at first event (years)	59.41	59.22	59.69

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	2.04 [1.34, 3.10]	9.6e-4	740
15 years	0.02	2.59 [1.86, 3.59]	1.3e-8	668
5 years	0.01	4.66 [3.66, 5.94]	1.2e-35	340
1 year	0.00	6.62 [4.94, 8.87]	8.5e-37	95

Correlations

↥

Index endpoint: K11_DIAHER – Diaphragmatic hernia
GWS hits: 6

Survival analyses between endpoints

↥

Plot

before Diaphragmatic hernia
after Diaphragmatic hernia

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Diaphragmatic hernia

↥