Personality disorders

mental retardation: ['Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual is mentally retarded. IQ scores between 70 and 79 are in the borderline mentally retarded range. Scores below 67 are in the retarded range. (Joynt, Clinical Neurology, 1992, Ch55, p28)']

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 F60, F61
Hospital discharge: ICD-9 31[0|2|4]|315A|31[6-8]
Hospital discharge: ICD-8 30100|301[2-9]
Cause of death: ICD-10 F60, F61
Cause of death: ICD-9 31[0|2|4]|315A|31[6-8]
Cause of death: ICD-8 30100|301[2-9]

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector KRA_PSY_PERSON

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 7121 4353 2768
Unadjusted prevalence (%) 2.74 2.96 2.45
Mean age at first event (years) 34.61 34.83 34.26

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.05 [1.43, 2.93] 9.4e-5 345
15 years 0.02 2.46 [1.78, 3.40] 4.8e-8 228
5 years 0.00 3.55 [2.49, 5.07] 3.3e-12 64
1 year 0.00 5.28 [3.05, 9.13] 2.7e-9 17

Correlations

Index endpoint: KRA_PSY_PERSON – Personality disorders
GWS hits: 0

Survival analyses between endpoints

Plot

before Personality disorders
after Personality disorders

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Personality disorders