Actinic keratosis

actinic keratosis: A precancerous lesion of the skin composed of atypical keratinocytes. It is characterized by the presence of thick, scaly patches of skin. Several histologic variants have been described, including atrophic, acantholytic, and hyperkeratotic variants.

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 L57.0
Hospital discharge: ICD-9 7020A
Hospital discharge: ICD-8 70200
Cause of death: ICD-10 L57.0
Cause of death: ICD-9 7020A
Cause of death: ICD-8 70200

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector L12_ACTINKERA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L57
Name in latin Keratosis actinica

Summary Statistics

Key figures

All Female Male
Number of individuals 5921 3072 2849
Unadjusted prevalence (%) 2.28 2.09 2.52
Mean age at first event (years) 71.11 70.34 71.94


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.83 [1.31, 2.54] 3.8e-4 664
15 years 0.01 2.07 [1.59, 2.69] 7.8e-8 635
5 years 0.00 2.95 [2.43, 3.58] 7.1e-28 338
1 year 0.00 2.43 [1.78, 3.32] 2.0e-8 59


Index endpoint: L12_ACTINKERA – Actinic keratosis
GWS hits: 15

Survival analyses between endpoints


before Actinic keratosis
after Actinic keratosis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Actinic keratosis