mixed connective tissue disease: Mixed connective tissue disease (MCTD) is a rare autoimmune disorder that is characterized by features commonly seen in three different connective tissue disorders: systemic lupus erythematosus , scleroderma , and polymyositis . Some affected people may also have symptoms of rheumatoid arthritis . Although MCTD can affect people of all ages, it appears to be most common in women under age 30. Signs and symptoms vary but may include Raynaud's phenomenon ; arthritis; heart, lung and skin abnormalities; kidney disease; muscle weakness, and dysfunction of the esophagus. The cause of MCTD is currently unknown. There is no cure but certain medications such as nonsteroidal anti-inflammatory drugs (NSAIDs) , corticosteroids and immunosuppresivedrugsmay help manage the symptoms.
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Check pre-conditions None
Include endpoints None
Check conditions None
Apply sex-specific rule None
M13_OVERLAP
Extra metadata
List of similar endpoints to
Other overlap syndromes
based on the number of shared cases.
Broader endpoints:
Narrower endpoints:
None
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 307 | 245 | 62 |
| Unadjusted prevalence (%) | 0.12 | 0.17 | 0.05 |
| Mean age at first event (years) | 52.01 | 50.88 | 56.49 |
| Follow-up | Absolute risk | HR [95% CI] | p | N |
|---|---|---|---|---|
| 1998–2019 | 0.12 | 8.86 [4.55, 17.25] | 1.4e-10 | 26 |
| 15 years | 0.05 | 8.11 [4.02, 16.37] | 5.1e-9 | 23 |
| 5 years | 0.01 | 12.13 [6.10, 24.14] | 1.2e-12 | 11 |
| 1 year | - | - | - | - |
Index endpoint: M13_OVERLAP – Other overlap syndromes
GWS hits: 0
before Other overlap syndromes
after Other overlap syndromes
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