Sicca syndrome [Sjögren]

DOID EFO MESH SNOMED PheWeb

Sjogren syndrome: an autoimmune disorder in which immune cells attack and destroy the glands that produce tears and saliva. Sjögren syndrome is also associated with rheumatic disorders such as rheumatoid arthritis or systemic lupus erythematosus. The hallmark symptoms of Sjögren syndrome are dry mouth and dry eyes. In addition, Sjogren syndrome may cause skin, nose, and vaginal dryness. It also may affect other organs of the body including the kidneys, blood vessels, lungs, liver, pancreas, and brain

Endpoint definition

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FinnGen phenotype data

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 M35.0

Hospital discharge: ICD-9 7102

Hospital discharge: ICD-8 73490

Cause of death: ICD-10 M35.0

Cause of death: ICD-9 7102

Cause of death: ICD-8 73490

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

M13_SJOGREN

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Parent code in ICD-10 M35

Name in latin Syndroma Sjögren

Similar endpoints

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List of similar endpoints to Sicca syndrome [Sjögren] based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	1606	1397	209
Unadjusted prevalence (%)	0.62	0.95	0.18
Mean age at first event (years)	53.01	52.56	56.04

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.70 [1.01, 2.85]	4.4e-2	114
15 years	0.01	1.78 [1.06, 3.00]	2.9e-2	95
5 years	0.00	2.88 [1.75, 4.74]	3.3e-5	35
1 year	0.00	5.76 [2.99, 11.08]	1.6e-7	13

Correlations

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Index endpoint: M13_SJOGREN – Sicca syndrome [Sjögren]
GWS hits: 4

Survival analyses between endpoints

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Plot

before Sicca syndrome [Sjögren]
after Sicca syndrome [Sjögren]

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Table

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Drugs most likely to be purchased after Sicca syndrome [Sjögren]

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