Sicca syndrome [Sjögren]

Sjogren syndrome: an autoimmune disorder in which immune cells attack and destroy the glands that produce tears and saliva. Sjögren syndrome is also associated with rheumatic disorders such as rheumatoid arthritis or systemic lupus erythematosus. The hallmark symptoms of Sjögren syndrome are dry mouth and dry eyes. In addition, Sjogren syndrome may cause skin, nose, and vaginal dryness. It also may affect other organs of the body including the kidneys, blood vessels, lungs, liver, pancreas, and brain

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 M35.0
Hospital discharge: ICD-9 7102
Hospital discharge: ICD-8 73490
Cause of death: ICD-10 M35.0
Cause of death: ICD-9 7102
Cause of death: ICD-8 73490

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector M13_SJOGREN

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M35
Name in latin Syndroma Sjögren

Summary Statistics

Key figures

All Female Male
Number of individuals 1606 1397 209
Unadjusted prevalence (%) 0.62 0.95 0.18
Mean age at first event (years) 53.01 52.56 56.04


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.70 [1.01, 2.85] 4.4e-2 114
15 years 0.01 1.78 [1.06, 3.00] 2.9e-2 95
5 years 0.00 2.88 [1.75, 4.74] 3.3e-5 35
1 year 0.00 5.76 [2.99, 11.08] 1.6e-7 13


Index endpoint: M13_SJOGREN – Sicca syndrome [Sjögren]
GWS hits: 4

Survival analyses between endpoints


before Sicca syndrome [Sjögren]
after Sicca syndrome [Sjögren]

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Sicca syndrome [Sjögren]