Myelofibrosis

primary myelofibrosis: Myelofibrosis with myeloid metaplasia is a myeloproliferative disease with annual incidence of approximately 1 case per 100,000 individuals and age at diagnosis around 60 (an increased prevalence is noted in Ashkenazi Jews). Clinical manifestations depend on the type of blood cell affected and may include anemia, pallor, splenomegaly, hypermetabolic state, petechiae, ecchymosis, bleeding, lymphadenopathy, hepatomegaly, portal hypertension.

Endpoint definition

FinnGen phenotype data
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Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 C94.5
Hospital discharge: ICD-9 2387A
Hospital discharge: ICD-8 209
Cause of death: ICD-10 C94.5
Cause of death: ICD-9 2387A
Cause of death: ICD-8 209

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector MYELOFIBROSIS

Extra metadata

First used in FinnGen datafreeze DF2, additional

Summary Statistics

Key figures

All Female Male
Number of individuals 9 - 6
Unadjusted prevalence (%) 0.00 - 0.01
Mean age at first event (years) 33.94 - 38.34

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Correlations

Index endpoint: MYELOFIBROSIS – Myelofibrosis
GWS hits:

Survival analyses between endpoints

Plot

before Myelofibrosis
after Myelofibrosis

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