Secondary parkinsonism

secondary Parkinson disease: Conditions which feature clinical manifestations resembling primary Parkinson disease that are caused by a known or suspected condition. Examples include parkinsonism caused by vascular injury, drugs, trauma, toxin exposure, neoplasms, infections and degenerative or hereditary conditions. Clinical features may include bradykinesia, rigidity, parkinsonian gait, and masked facies. In general, tremor is less prominent in secondary parkinsonism than in the primary form. (From Joynt, Clinical Neurology, 1998, Ch38, pp39-42)

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 G21
Hospital discharge: ICD-9 3321
Cause of death: ICD-10 G21
Cause of death: ICD-9 3321

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector PD2ND

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 G20-G26
Name in latin Parkinsonismus secundarius

Summary Statistics

Key figures

All Female Male
Number of individuals 480 209 271
Unadjusted prevalence (%) 0.18 0.14 0.24
Mean age at first event (years) 60.19 60.25 60.14

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Correlations

Index endpoint: PD2ND – Secondary parkinsonism
GWS hits: 1

Survival analyses between endpoints

Plot

before Secondary parkinsonism
after Secondary parkinsonism

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Drugs most likely to be purchased after Secondary parkinsonism