Polycythaemia vera

chronic myeloproliferative disorder: A clonal hematopoietic stem cell disorder, characterized by proliferation in the bone marrow of one or more of the myeloid (i.e., granulocytic, erythroid, megakaryocytic, and mast cell) lineages. It is primarily a neoplasm of adults. (WHO 2008)

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 D45
Hospital discharge: ICD-9 2384
Hospital discharge: ICD-8 208
Cause of death: ICD-10 D45
Cause of death: ICD-9 2384
Cause of death: ICD-8 208

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector POLYCYTVERA

Extra metadata

First used in FinnGen datafreeze DF2, additional

Summary Statistics

Key figures

All Female Male
Number of individuals 483 244 239
Unadjusted prevalence (%) 0.19 0.17 0.21
Mean age at first event (years) 61.65 61.76 61.53

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 3.36 [1.58, 7.15] 1.6e-3 84
15 years 0.03 4.43 [2.35, 8.36] 4.3e-6 79
5 years 0.01 6.17 [3.82, 9.97] 1.0e-13 35
1 year - - - -

Correlations

Index endpoint: POLYCYTVERA – Polycythaemia vera
GWS hits: 8

Survival analyses between endpoints

Plot

before Polycythaemia vera
after Polycythaemia vera

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Drugs most likely to be purchased after Polycythaemia vera