Polycythaemia vera

chronic myeloproliferative disorder: A clonal hematopoietic stem cell disorder, characterized by proliferation in the bone marrow of one or more of the myeloid (i.e., granulocytic, erythroid, megakaryocytic, and mast cell) lineages. It is primarily a neoplasm of adults. (WHO 2008)

Endpoint definition

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FinnGen phenotype data
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Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 D45
Hospital discharge: ICD-9 2384
Hospital discharge: ICD-8 208
Cause of death: ICD-10 D45
Cause of death: ICD-9 2384
Cause of death: ICD-8 208

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector POLYCYTVERA

Extra metadata

First used in FinnGen datafreeze DF2, additional

Summary Statistics

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Key figures

All Female Male
Number of individuals 483 244 239
Unadjusted prevalence (%) 0.19 0.17 0.21
Mean age at first event (years) 61.65 61.76 61.53

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 3.36 [1.58, 7.15] 1.6e-3 84
15 years 0.03 4.43 [2.35, 8.36] 4.3e-6 79
5 years 0.01 6.17 [3.82, 9.97] 1.0e-13 35
1 year - - - -

Correlations

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Index endpoint: POLYCYTVERA – Polycythaemia vera
GWS hits: 8

Survival analyses between endpoints

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Plot

before Polycythaemia vera
after Polycythaemia vera

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Polycythaemia vera

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