Fasciculation

persistent fetal circulation syndrome: A syndrome of persistent PULMONARY HYPERTENSION in the newborn infant (INFANT, NEWBORN) without demonstrable HEART DISEASES. This neonatal condition can be caused by severe pulmonary vasoconstriction (reactive type), hypertrophy of pulmonary arterial muscle (hypertrophic type), or abnormally developed pulmonary arterioles (hypoplastic type). The newborn patient exhibits CYANOSIS and ACIDOSIS due to the persistence of fetal circulatory pattern of right-to-left shunting of blood through a patent ductus arteriosus (DUCTUS ARTERIOSUS, PATENT) and at times a patent foramen ovale (FORAMEN OVALE, PATENT).

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 R25.3
Cause of death: ICD-10 R25.3

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector R18_FASCICULATION

Extra metadata

Level in the ICD hierarchy 4
Special FASCICULATION
First used in FinnGen datafreeze DF4
Parent code in ICD-10 R25
Name in latin Fasciculationes

Summary Statistics

Key figures

All Female Male
Number of individuals 164 85 79
Unadjusted prevalence (%) 0.06 0.06 0.07
Mean age at first event (years) 49.87 44.89 55.23

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Correlations

Index endpoint: R18_FASCICULATION – Fasciculation
GWS hits: 0

Survival analyses between endpoints

Plot

before Fasciculation
after Fasciculation

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