General symptoms and signs

No definition available.

Endpoint definition

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FinnGen phenotype data

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Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 R50-R69

Cause of death: ICD-10 R50-R69

Check pre-conditions None

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Include endpoints

R18_FEVER_OTHER_UNKNO_ORIGIN

R18_PAIN_NOT_ELSEW_CLASSIFIED

R18_MALAI_FATIG

R18_SYNCO_COLLAP

R18_CONVU_NOT_ELSEW_CLASSIFIED

R18_SHOCK_NOT_ELSEW_CLASSIFIED

R18_HAEMORRHAGE_NOT_ELSEW_CLASSIFIED

R18_ENLARGED_LYMPH_NODES

R18_OEDEMA_NOT_ELSEW_CLASSIFIED

R18_HYPERHIDROSIS

R18_LACK_EXPEC_NORMAL_PHYSIO_DEVELOPMENT

R18_SYMPTOMS_SIGNS_CONCERNI_FOOD_FLUID_INTAKE

R18_OTHER_GENERAL_SYMPTOMS_SIGNS

R18_UNKNO_UNSPE_CAUSES_MORBIDI

Check conditions None

Apply sex-specific rule None

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R18_GENERAL_SYMPTOMS_SIGNS

Extra metadata

Level in the ICD hierarchy 2

First used in FinnGen datafreeze DF4

Parent code in ICD-10 R

Name in latin Symptomata et signa generalia

Similar endpoints

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List of similar endpoints to General symptoms and signs based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	56065	32301	23764
Unadjusted prevalence (%)	21.56	21.98	21.02
Mean age at first event (years)	51.36	48.84	54.78

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.06	4.55 [4.11, 5.04]	<1e-100	7629
15 years	0.03	5.30 [4.86, 5.79]	<1e-100	7113
5 years	0.01	9.86 [9.10, 10.68]	<1e-100	4693
1 year	0.00	19.77 [17.51, 22.32]	<1e-100	2134

Correlations

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Index endpoint: R18_GENERAL_SYMPTOMS_SIGNS – General symptoms and signs
GWS hits: 2

Survival analyses between endpoints

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Plot

before General symptoms and signs
after General symptoms and signs

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Table

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Drugs most likely to be purchased after General symptoms and signs

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