Thromboangiitis obliterans

thromboangiitis obliterans: Buerger disease, also known as thromboangiitis obliterans (TAO), is a rare inflammatory non-necrotizing vascular disease affecting the small- and medium-sized arteries and veins of the upper and lower extremities characterized by endarteritis and vaso-occlusion due to occlusive thrombus development. The development and progression of the disease is consistently associated with exposure to tobacco.

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 I73.1
Hospital discharge: ICD-9 4431A
Hospital discharge: ICD-8 44310
Cause of death: ICD-10 I73.1
Cause of death: ICD-9 4431A
Cause of death: ICD-8 44310

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector I9_THROMBANG

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 I73
Name in latin Tromboangi(i)tis obliterans (Bürger)

Summary Statistics

Key figures

All Female Male
Number of individuals 70 27 43
Unadjusted prevalence (%) 0.03 0.02 0.04
Mean age at first event (years) 48.68 46.24 50.21

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Correlations

Index endpoint: I9_THROMBANG – Thromboangiitis obliterans
GWS hits:

Survival analyses between endpoints

Plot

before Thromboangiitis obliterans
after Thromboangiitis obliterans

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Drugs most likely to be purchased after Thromboangiitis obliterans