Asthma (only as main-diagnosis)

asthma: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.

Endpoint definition

FinnGen phenotype data
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Filter registries Inpat., Oupat., Death

Hospital Discharge: only main entry used Yes
Hospital Discharge: ICD-10 J45, J46
Hospital discharge: ICD-9 493
Hospital discharge: ICD-8 493
Cause of death: only main entry used Yes
Cause of death: ICD-10 J45, J46
Cause of death: ICD-9 493
Cause of death: ICD-8 493

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector J10_ASTHMA_MAIN

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 21354 13268 8086
Unadjusted prevalence (%) 8.21 9.03 7.15
Mean age at first event (years) 42.05 41.39 43.13

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.74 [1.47, 2.05] 8.5e-11 1948
15 years 0.01 1.98 [1.69, 2.32] 1.3e-17 1488
5 years 0.00 3.00 [2.59, 3.46] 2.3e-50 548
1 year 0.00 3.53 [2.81, 4.44] 3.3e-27 119

Correlations

Index endpoint: J10_ASTHMA_MAIN – Asthma (only as main-diagnosis)
GWS hits: 27

Survival analyses between endpoints

Plot

before Asthma (only as main-diagnosis)
after Asthma (only as main-diagnosis)

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Asthma (only as main-diagnosis)