asthma: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 J45, J46
Hospital discharge: ICD-9 493
Hospital discharge: ICD-8 493
Cause of death: ICD-10 J45, J46
Cause of death: ICD-9 493
Cause of death: ICD-8 493

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector J10_ASTHMA

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 25540 15726 9814
Unadjusted prevalence (%) 9.82 10.70 8.68
Mean age at first event (years) 44.17 43.26 45.63


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.91 [1.65, 2.21] 2.3e-18 2559
15 years 0.02 2.31 [2.05, 2.61] 4.0e-42 2049
5 years 0.00 3.83 [3.41, 4.29] <1e-100 863
1 year 0.00 6.08 [5.10, 7.24] 4.3e-91 256


Index endpoint: J10_ASTHMA – Asthma
GWS hits: 27

Survival analyses between endpoints


before Asthma
after Asthma

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