Asthma (mode)

asthma: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.

Endpoint definition

FinnGen phenotype data
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Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 (mode) J45, J46
Hospital discharge: ICD-9 493
Hospital discharge: ICD-8 493
Cause of death: ICD-10 (mode) J45, J46
Cause of death: ICD-9 493
Cause of death: ICD-8 493

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector ASTHMA_MODE

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 24160 15250 8910
Unadjusted prevalence (%) 9.29 10.38 7.88
Mean age at first event (years) 43.20 42.78 43.92


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.81 [1.51, 2.16] 6.6e-11 2080
15 years 0.01 2.15 [1.86, 2.48] 2.4e-25 1628
5 years 0.00 3.54 [3.11, 4.04] 2.2e-79 692
1 year 0.00 6.23 [5.16, 7.53] 8.8e-81 225


Index endpoint: ASTHMA_MODE – Asthma (mode)
GWS hits: 30

Survival analyses between endpoints


before Asthma (mode)
after Asthma (mode)

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