Asthma, hospital admissions , main diagnosis only

asthma: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.

Endpoint definition

FinnGen phenotype data
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Filter registries Inpat., Oupat.

Hospital Discharge: only main entry used Yes
Hospital Discharge: ICD-10 J45, J46
Hospital discharge: ICD-9 493
Hospital discharge: ICD-8 493

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector ASTHMA_HOSPITAL_MAIN

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 21349 13266 8083
Unadjusted prevalence (%) 8.21 9.03 7.15
Mean age at first event (years) 42.05 41.39 43.13

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.63 [1.38, 1.93] 1.2e-8 1943
15 years 0.01 1.96 [1.70, 2.26] 9.9e-21 1483
5 years 0.00 2.94 [2.57, 3.36] 3.2e-55 543
1 year 0.00 3.38 [2.69, 4.24] 6.4e-26 114

Correlations

Index endpoint: ASTHMA_HOSPITAL_MAIN – Asthma, hospital admissions , main diagnosis only
GWS hits: 21

Survival analyses between endpoints

Plot

before Asthma, hospital admissions , main diagnosis only
after Asthma, hospital admissions , main diagnosis only

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Drugs most likely to be purchased after Asthma, hospital admissions , main diagnosis only