Degenerative macular diseases

macular degeneration: Loss of vision in the central portion of the retina (macula), secondary to retinal degeneration. [ NCIT:P378 ]

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 H35.39#
Cause of death: ICD-10 H35.39#

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector MACULA_NAS

Extra metadata

Level in the ICD hierarchy 5
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H35
Name in latin Striae angioides maculae

Summary Statistics

Key figures

All Female Male
Number of individuals 2077 1142 935
Unadjusted prevalence (%) 0.80 0.78 0.83
Mean age at first event (years) 65.75 65.18 66.43

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.65 [1.87, 3.75] 4.4e-8 294
15 years 0.02 2.96 [2.22, 3.96] 2.0e-13 277
5 years 0.00 3.50 [2.60, 4.72] 1.3e-16 104
1 year 0.00 4.29 [2.68, 6.85] 1.2e-9 23

Correlations

Index endpoint: MACULA_NAS – Degenerative macular diseases
GWS hits: 1

Survival analyses between endpoints

Plot

before Degenerative macular diseases
after Degenerative macular diseases

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Degenerative macular diseases