Alzheimer’s disease (Atypical or mixed)

Alzheimer's disease: A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 F00.24*, G30.8, G30.8+F00.20
Cause of death: ICD-10 F00.24*, G30.8, G30.8+F00.20

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector AD_AM

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 946 440 506
Unadjusted prevalence (%) 0.36 0.30 0.45
Mean age at first event (years) 80.45 81.43 79.60

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.25 18.93 [14.15, 25.33] 3.7e-87 581
15 years 0.13 18.93 [14.15, 25.33] 3.7e-87 581
5 years - - - -
1 year - - - -

Correlations

Index endpoint: AD_AM – Alzheimer’s disease (Atypical or mixed)
GWS hits: 2

Survival analyses between endpoints

Plot

before Alzheimer’s disease (Atypical or mixed)
after Alzheimer’s disease (Atypical or mixed)

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Alzheimer’s disease (Atypical or mixed)