Alzheimer’s disease (Early onset)

DOID EFO MESH SNOMED PheWeb

Alzheimer's disease: A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.

Endpoint definition

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FinnGen phenotype data

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 F00.0*, F00.00*, F00.00*G30.0, G30.0, G30.0+F00.00

Cause of death: ICD-10 F00.0*, F00.00*, F00.00*G30.0, G30.0, G30.0+F00.00

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

AD_EO

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Alzheimer’s disease (Early onset) based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	680	344	336
Unadjusted prevalence (%)	0.26	0.23	0.30
Mean age at first event (years)	74.95	74.47	75.45

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Correlations

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Index endpoint: AD_EO – Alzheimer’s disease (Early onset)
GWS hits: 1

Survival analyses between endpoints

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Plot

before Alzheimer’s disease (Early onset)
after Alzheimer’s disease (Early onset)

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Table

Loading survival analyses table

Drugs most likely to be purchased after Alzheimer’s disease (Early onset)

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