Alzheimer’s disease (Late onset)

DOID EFO MESH SNOMED PheWeb

Alzheimer's disease: A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.

Endpoint definition

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FinnGen phenotype data

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 F00.1*, F00.10*, F00.10*G30.1, G30.1, G30.1+F00.10

Cause of death: ICD-10 F00.1*, F00.10*, F00.10*G30.1, G30.1, G30.1+F00.10

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

AD_LO

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Alzheimer’s disease (Late onset) based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	3103	1586	1517
Unadjusted prevalence (%)	1.19	1.08	1.34
Mean age at first event (years)	79.53	80.03	79.00

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.18	12.24 [10.64, 14.09]	<1e-100	1801
15 years	0.09	12.37 [10.78, 14.20]	<1e-100	1794
5 years	0.00	0.37 [0.00, 46.95]	6.9e-1	1310
1 year	-	-	-	-

Correlations

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Index endpoint: AD_LO – Alzheimer’s disease (Late onset)
GWS hits: 2

Survival analyses between endpoints

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Plot

before Alzheimer’s disease (Late onset)
after Alzheimer’s disease (Late onset)

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Alzheimer’s disease (Late onset)

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