Asthma-related pneumonia or sepsis

asthma: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.

Endpoint definition

FinnGen phenotype data

Filter registries None

Check pre-conditions None

diagram bullet diagram downward connector

Check conditions

J10_ASTHMA

Apply sex-specific rule None

diagram downward connector ASTHMA_PNEUMONIA_AND_SEPSIS

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 6918 3725 3193
Unadjusted prevalence (%) 2.66 2.53 2.82
Mean age at first event (years) 52.84 51.06 54.93

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.07 4.91 [3.92, 6.16] 2.7e-43 1529
15 years 0.04 5.75 [4.78, 6.91] 1.1e-77 1407
5 years - - - -
1 year - - - -

Correlations

Index endpoint: ASTHMA_PNEUMONIA_AND_SEPSIS – Asthma-related pneumonia or sepsis
GWS hits: 3

Survival analyses between endpoints

Plot

before Asthma-related pneumonia or sepsis
after Asthma-related pneumonia or sepsis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Asthma-related pneumonia or sepsis