Atopic dermatitis, strict definition with reimbursement

atopic eczema: A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.

Endpoint definition

FinnGen phenotype data
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Filter registries KELA purch., KELA reimb.

KELA reimbursements: KELA codes 134|395|317

Check pre-conditions None

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Include endpoints

Check conditions None

Apply sex-specific rule None

diagram downward connector ATOPIC_STRICT_REIMB

Extra metadata

First used in FinnGen datafreeze DF3

Summary Statistics

Key figures

All Female Male
Number of individuals 6739 4611 2128
Unadjusted prevalence (%) 2.59 3.14 1.88
Mean age at first event (years) 27.51 27.47 27.59

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.97 [1.36, 2.84] 3.1e-4 168
15 years 0.02 2.19 [1.51, 3.16] 3.3e-5 121
5 years 0.00 3.37 [2.14, 5.32] 1.8e-7 44
1 year 0.00 4.73 [2.40, 9.29] 6.7e-6 11

Correlations

Index endpoint: ATOPIC_STRICT_REIMB – Atopic dermatitis, strict definition with reimbursement
GWS hits: 27

Survival analyses between endpoints

Plot

before Atopic dermatitis, strict definition with reimbursement
after Atopic dermatitis, strict definition with reimbursement

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Drugs most likely to be purchased after Atopic dermatitis, strict definition with reimbursement