Diffuse large B-cell lymphoma

diffuse large B-cell lymphoma: Diffuse large B-cell lymphoma is the most common subtype of non-Hodgkin lymphoma (NHL; see this term) in adults characterized by a median age of presentation in the sixth decade of life (but also rarely occurring in adolescents and children) with the initial presentation being single or multiple rapidly growing masses (that may or may not be painful) in nodal or extranodal sites (such as thyroid, skin, breast, gastrointestinal tract, testes, bone, or brain) and that can be accompanied by symptoms of fever, night sweats and weight loss. DLBCL has an aggressive disease course, with the elderly having a poorer prognosis than younger patients, and with relapses being common.

Endpoint definition

FinnGen phenotype data
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Filter registries Death, Cancer

Cause of death: ICD-10 C83, C84, C85
Cause of death: ICD-9 200
Cause of death: ICD-8 200
Cancer registry: Topography ICD-O-3 C42|C77
Cancer registry: Morphology ICD-O-3 9680
Cancer registry: Behaviour codes 3

Check pre-conditions None

Include endpoints None

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Check conditions

HLP_C3_DLBCL

Apply sex-specific rule None

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Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF4

Summary Statistics

Key figures

All Female Male
Number of individuals 327 154 173
Unadjusted prevalence (%) 0.13 0.10 0.15
Mean age at first event (years) 64.84 63.71 65.85

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Correlations

Index endpoint: C3_DLBCL – Diffuse large B-cell lymphoma
GWS hits: 0

Survival analyses between endpoints

Plot

before Diffuse large B-cell lymphoma
after Diffuse large B-cell lymphoma

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Drugs most likely to be purchased after Diffuse large B-cell lymphoma