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Carcinoma in situ of breast, intraductal

DOIDEFOMESH PheWeb

breast ductal carcinoma in situ: A carcinoma entirely confined to the mammary ducts. It is also known as DCIS. There is no evidence of invasion of the basement membrane. Currently, it is classified into three categories: High-grade DCIS, intermediate-grade DCIS and low-grade DCIS. In this classification the DCIS grade is defined by a combination of nuclear grade, architectural growth pattern and presence of necrosis. The size of the lesion as well as the grade and the clearance margins play a major role in dictating the most appropriate therapy for DCIS.

Endpoint definition

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FinnGen phenotype data
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Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 D05.1&
Cause of death: ICD-10 D05.1&

Check pre-conditions None

Include endpoints None

Check conditions None

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Apply sex-specific rule

Sex only females
diagram downward connector CD2_INSITU_BREAST_INTRADUCTAL

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D05
Name in latin Carcinoma in situ intraductale mammae

Summary Statistics

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Key figures

All Female Male
Number of individuals 1241 1241 -
Unadjusted prevalence (%) 0.48 0.84 -
Mean age at first event (years) 59.49 59.49 -

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.33 [0.71, 2.51] 3.8e-1 44
15 years 0.01 1.52 [0.81, 2.83] 1.9e-1 41
5 years 0.00 2.19 [1.08, 4.43] 2.9e-2 19
1 year - - - -

Correlations

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Index endpoint: CD2_INSITU_BREAST_INTRADUCTAL – Carcinoma in situ of breast, intraductal
GWS hits: 1

Survival analyses between endpoints

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Plot

before Carcinoma in situ of breast, intraductal
after Carcinoma in situ of breast, intraductal

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Carcinoma in situ of breast, intraductal

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