Biliary chirrosis, primary

primary biliary cirrhosis: Primary biliary cholangitis (PBC) is a chronic and slowly progressive cholestatic liver disease of autoimmune etiology characterized by injury of the intrahepatic bile ducts that may eventually lead to liver failure.

Endpoint definition

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FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 K74.3
Cause of death: ICD-10 K74.3

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector CHIRBIL_PRIM

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 K74
Name in latin Cirrhosis biliaris [primaria]

Summary Statistics

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Key figures

All Female Male
Number of individuals 346 293 53
Unadjusted prevalence (%) 0.13 0.20 0.05
Mean age at first event (years) 55.61 55.11 58.36

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.97 [0.75, 5.13] 1.7e-1 33
15 years 0.02 2.82 [1.20, 6.63] 1.8e-2 29
5 years 0.01 6.07 [2.66, 13.85] 1.8e-5 13
1 year - - - -

Correlations

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Index endpoint: CHIRBIL_PRIM – Biliary chirrosis, primary
GWS hits: 0

Survival analyses between endpoints

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Plot

before Biliary chirrosis, primary
after Biliary chirrosis, primary

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Biliary chirrosis, primary

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