Biliary chirrosis, primary

primary biliary cirrhosis: Primary biliary cholangitis (PBC) is a chronic and slowly progressive cholestatic liver disease of autoimmune etiology characterized by injury of the intrahepatic bile ducts that may eventually lead to liver failure.

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 K74.3
Cause of death: ICD-10 K74.3

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector CHIRBIL_PRIM

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 K74
Name in latin Cirrhosis biliaris [primaria]

Summary Statistics

Key figures

All Female Male
Number of individuals 346 293 53
Unadjusted prevalence (%) 0.13 0.20 0.05
Mean age at first event (years) 55.61 55.11 58.36

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.97 [0.75, 5.13] 1.7e-1 33
15 years 0.02 2.82 [1.20, 6.63] 1.8e-2 29
5 years 0.01 6.07 [2.66, 13.85] 1.8e-5 13
1 year - - - -

Correlations

Index endpoint: CHIRBIL_PRIM – Biliary chirrosis, primary
GWS hits: 0

Survival analyses between endpoints

Plot

before Biliary chirrosis, primary
after Biliary chirrosis, primary

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Biliary chirrosis, primary