Fibrosis and chirrhosis of liver

cirrhosis of liver: A disorder characterized by replacement of the liver parenchyma with fibrous tissue and regenerative nodules. It is usually caused by alcoholism, hepatitis B, and hepatitis C. Complications include the development of ascites, esophageal varices, bleeding, and hepatic encephalopathy.

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 K74
Hospital discharge: ICD-9 571[5-6]
Hospital discharge: ICD-8 5719
Cause of death: ICD-10 K74
Cause of death: ICD-9 571[5-6]
Cause of death: ICD-8 5719

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector K11_FIBROCHIRLIV

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K70-K77
Name in latin Fibrosis et cirrhosis hepatis

Summary Statistics

Key figures

All Female Male
Number of individuals 1036 567 469
Unadjusted prevalence (%) 0.40 0.39 0.41
Mean age at first event (years) 58.17 56.06 60.74

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.11 8.29 [4.76, 14.43] 7.5e-14 271
15 years 0.07 11.57 [7.14, 18.75] 2.9e-23 265
5 years - - - -
1 year - - - -

Correlations

Index endpoint: K11_FIBROCHIRLIV – Fibrosis and chirrhosis of liver
GWS hits: 3

Survival analyses between endpoints

Plot

before Fibrosis and chirrhosis of liver
after Fibrosis and chirrhosis of liver

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Fibrosis and chirrhosis of liver