Cryoglobulinemia

cryoglobulinemia: Cryoglobulinemia is a type of vasculitis that is caused by abnormal proteins (antibodies) in the blood called 'cryoglobulins.' At cold temperatures, these proteins become solid or gel-like, which can block blood vessels and cause a variety of health problems. Many people affected by this condition will not experience any unusual signs or symptoms. When present, symptoms vary but may include breathing problems; fatigue; glomerulonephritis ; joint or muscle pain; purpura ; Raynaud's phenomenon ; skin death; and/or skin ulcers. In some cases, the exact underlying cause is unknown; however, cryoglobulinemia can be associated with a variety of conditions including certain types of infection; chronic inflammatory diseases (such as autoimmune disease ); and/or cancers of the blood or immune system . Treatment varies based on the severity of the condition, the symptoms present in each person and the underlying cause.

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 D89.1
Hospital discharge: ICD-9 2732A
Hospital discharge: ICD-8 2754
Cause of death: ICD-10 D89.1
Cause of death: ICD-9 2732A
Cause of death: ICD-8 2754

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector D3_CRYOGLOBU

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D89
Name in latin Cryoglobulinaemia

Summary Statistics

Key figures

All Female Male
Number of individuals 24 10 14
Unadjusted prevalence (%) 0.01 0.01 0.01
Mean age at first event (years) 50.31 47.03 52.66

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Correlations

Index endpoint: D3_CRYOGLOBU – Cryoglobulinemia
GWS hits:

Survival analyses between endpoints

Plot

before Cryoglobulinemia
after Cryoglobulinemia

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Cryoglobulinemia