Sarcoidosis

obsolete_sarcoidosis: ['An idiopathic inflammatory disorder characterized by the formation of non-necrotizing epithelioid granulomas which contain giant cells. It usually affects the lungs, lymph nodes, liver, and skin.', 'An idiopathic systemic inflammatory granulomatous disorder comprised of epithelioid and multinucleated giant cells with little necrosis. It usually invades the lungs with fibrosis and may also involve lymph nodes, skin, liver, spleen, eyes, phalangeal bones, and parotid glands.']

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death, KELA purch., KELA reimb.

Hospital Discharge: ICD-10 D86
Hospital discharge: ICD-9 135
Hospital discharge: ICD-8 135
Cause of death: ICD-10 D86
Cause of death: ICD-9 135
Cause of death: ICD-8 135
KELA reimbursements: KELA codes 132

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector D3_SARCOIDOSIS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D80-D89
Name in latin Sarcoidosis

Summary Statistics

Key figures

All Female Male
Number of individuals 2496 1394 1102
Unadjusted prevalence (%) 0.96 0.95 0.97
Mean age at first event (years) 45.98 46.70 45.07

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.38 [0.97, 1.96] 7.4e-2 189
15 years 0.01 1.63 [1.18, 2.26] 3.4e-3 126
5 years 0.00 3.17 [2.21, 4.54] 3.4e-10 50
1 year 0.00 7.10 [4.30, 11.71] 1.8e-14 20

Correlations

Index endpoint: D3_SARCOIDOSIS – Sarcoidosis
GWS hits: 9

Survival analyses between endpoints

Plot

before Sarcoidosis
after Sarcoidosis

loading spinner Loading survival analyses plot