Other diabetes, wide definition

Takayasu arteritis: Takayasu arteritis (TAK) is a rare inflammatory large-vessel vasculitis primarily affecting the aorta and its major branches, but also other large vessels, causing stenosis, occlusion, or aneurysm.

Endpoint definition

FinnGen phenotype data
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Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 E13
Cause of death: ICD-10 E13

Check pre-conditions None

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Include endpoints

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Check conditions

not GEST_DIABETES

Apply sex-specific rule None

diagram downward connector DM_OTHER_WIDE

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 40150 17337 22813
Unadjusted prevalence (%) 15.44 11.80 20.17
Mean age at first event (years) 55.84 55.68 55.96

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.65 [2.40, 2.93] 1.5e-80 5892
15 years 0.02 2.83 [2.60, 3.08] <1e-100 4802
5 years 0.00 3.33 [3.05, 3.64] <1e-100 1599
1 year 0.00 2.58 [2.17, 3.08] 2.0e-26 234

Correlations

Index endpoint: DM_OTHER_WIDE – Other diabetes, wide definition
GWS hits: 89

Survival analyses between endpoints

Plot

before Other diabetes, wide definition
after Other diabetes, wide definition

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Drugs most likely to be purchased after Other diabetes, wide definition