Dry age-related macular degeneration (includes geographic atrophy)

age-related macular degeneration: Age-related loss of vision in the central portion of the retina (macula), secondary to retinal degeneration.

Endpoint definition

FinnGen phenotype data
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Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 H35.30
Hospital discharge: ICD-9 3625A
Cause of death: ICD-10 H35.30
Cause of death: ICD-9 3625A
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Check pre-conditions

Pre-conditions EVENT_AGE>=50

Include endpoints None

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Check conditions

not DRY_AMD_EARLY

Apply sex-specific rule None

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Extra metadata

Level in the ICD hierarchy 5
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H35
Name in latin Degeneratio maculae senilis atrophica

Summary Statistics

Key figures

All Female Male
Number of individuals 3068 1699 1369
Unadjusted prevalence (%) 1.18 1.16 1.21
Mean age at first event (years) 74.61 74.95 74.20

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.55 [1.90, 3.42] 4.6e-10 674
15 years - - - -
5 years - - - -
1 year - - - -

Correlations

Index endpoint: DRY_AMD – Dry age-related macular degeneration (includes geographic atrophy)
GWS hits: 5

Survival analyses between endpoints

Plot

before Dry age-related macular degeneration (includes geographic atrophy)
after Dry age-related macular degeneration (includes geographic atrophy)

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Drugs most likely to be purchased after Dry age-related macular degeneration (includes geographic atrophy)