Acromegaly and pituitary gigantism

hyperpituitarism: Disease of the glandular, anterior portion of the pituitary (pituitary gland, anterior) resulting in hypersecretion of adenohypophyseal hormones such as growth hormone; prolactin; thyrotropin; luteinizing hormone; follicle stimulating hormone ; and adrenocorticotropic hormone. Hyperpituitarism usually is caused by a functional adenoma.

Endpoint definition

FinnGen phenotype data
diagram bullet diagram downward connector

Filter registries Inpat., Oupat., Death

Hospital Discharge: ICD-10 E22.0
Hospital discharge: ICD-9 2530
Hospital discharge: ICD-8 2530
Hospital discharge: excluded ICD-8 25301
Cause of death: ICD-10 E22.0
Cause of death: ICD-9 2530
Cause of death: ICD-8 2530
Cause of death: excluded ICD-8 25301

Check pre-conditions None

Include endpoints None

Check conditions None

Apply sex-specific rule None

diagram downward connector E4_ACROMEG

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E22
Name in latin Acromegalia

Summary Statistics

Key figures

All Female Male
Number of individuals 130 80 50
Unadjusted prevalence (%) 0.05 0.05 0.04
Mean age at first event (years) 44.81 43.95 46.19

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Correlations

Index endpoint: E4_ACROMEG – Acromegaly and pituitary gigantism
GWS hits: 0

Survival analyses between endpoints

Plot

before Acromegaly and pituitary gigantism
after Acromegaly and pituitary gigantism

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Drugs most likely to be purchased after Acromegaly and pituitary gigantism